RT Book, Section
A1 Tower, Amelia
A1 Robin, Julieta
A1 Duggal, Shivani
A1 Julian, Thomas B.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145759781
T1 Landmark Clinical Trials that Impacted Surgical Management of Invasive and Noninvasive Breast Cancer
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145759781
RD 2024/04/19
AB Over  the  last  four  decades,  there  has  been  a  paradigm  shift  in  the  management  of  breast  cancer  as  a  result  of  several  landmark  clinical  trials  conducted  in  the  United  States  and  Europe  that  are  responsible  for  the  new  standards  of  breast  cancer  care  worldwide.  Advances  from  these  clinical  trials  transformed  the  treatment  of  breast  cancer  by  advocating  less  radical  surgery  and  introducing  the  use  of  innovative  techniques  in  conjunction  with  other  modalities  including  systemic  chemotherapy,  endocrine  therapy,  and  radiotherapy  (RT).  This  subsequently  led  to  a  multidisciplinary  approach  to  breast  cancer  and  is  further  leading  to  individualized  treatment  for  each  patient.  This  chapter  provides  a  review  of  the  significant  landmark  clinical  trials  that  revolutionized  the  management  and  that  currently  guide  the  surgical  practice  of  noninvasive  and  invasive  breast  cancer.