RT Book, Section
A1 Singh, Puneet
A1 Kulkarni, Swati
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145759946
T1 Surgical Strategies for Breast Cancer Risk Reduction
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145759946
RD 2024/04/24
AB Surgical  prophylaxis  remains  the  most  effective  means  to  prevent  breast  cancer.  Strategies  for  risk  reduction  include  bilateral  prophylactic  mastectomy  (BPM),  contralateral  prophylactic  mastectomy  (CPM),  and  prophylactic  bilateral  salpingo-oophorectomy  (PBSO).  BPM  is  performed  for  risk  reduction  in  women  who  have  not  been  diagnosed  with  cancer.  In  contrast,  CPM  is  performed  in  patients  with  a  diagnosis  of  unilateral  breast  cancer  for  risk  reduction  of  contralateral  breast  cancer.1  Current  guidelines  for  prophylactic  mastectomy  (PM)  include  patients  with  BRCA1/2  mutations,  other  predisposing  gene  mutations,  strong  family  history  with  no  demonstrable  mutation,  and  prior  mantle  radiation  for  Hodgkin’s  lymphoma,  all  of  which  confer  a  significantly  higher  risk  for  breast  cancer  than  for  the  general  population.2,3  Discussion  of  risk-reduction  procedures  is  complex  and  should  be  individualized  to  ensure  the  best  oncologic  and  psychosocial  outcomes  for  each  patient.