RT Book, Section A1 Koonce, Stephanie A1 McLaughlin, Sarah A. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145760904 T1 Survivorship Issues in Breast Cancer T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK hemonc.mhmedical.com/content.aspx?aid=1145760904 RD 2024/04/24 AB Improvements in diagnosis and advances in targeted therapies have contributed to the increasing numbers of breast cancer survivors. The most recent estimate by the Surveillance Epidemiology and End Results (SEER) database estimates nearly 2.8 million breast cancer survivors alive as of 2013, an increase from previous estimates.1 As the numbers of survivors have increased and as many of those survivors are living decades beyond their treatment, issues affecting survivorship and overall quality of life (QOL) have moved to the forefront of breast cancer research. Identification and classification of the persistent and late consequences of breast cancer treatment have become critical endpoints in many newly developed clinical trials. In fact, with the input of patient advocates contemporary clinical trial development frequently includes assessment of outcomes equally according to efficacy and anticipated impact on future QOL.