RT Book, Section A1 Herbert, Garth S. A1 Nash, Garrett M. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145762020 T1 Appendiceal Neoplasms T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK hemonc.mhmedical.com/content.aspx?aid=1145762020 RD 2024/03/28 AB The appendix is a rare site of malignancy, with a large variety of histologic subtypes. Reviews of large series of appendectomies reveal appendiceal neoplasms in nearly 0.7% to 0.9% of cases.1,2 Even with the large number of appendectomies performed annually in the United States, appendiceal malignancies remain a rare entity, comprising less than 1% of colorectal malignancies. The age-adjusted risk of development of appendiceal cancer is estimated at just 0.12 cases per 1,000,000 per year.3,4 The rarity of the diagnosis makes database reviews and small series the primary source of information regarding frequency of diagnoses and outcomes. McCusker was the first to conduct a review of the SEER database, reviewing 2117 appendiceal malignancies reported to SEER between 1973 and 1998.4 Additional SEER reviews based on the same population but extending the time interval slightly have been published by McGory and Turaga, revealing fairly similar results.5,6