RT Book, Section
A1 Geurts, Jennifer
A1 Evans, Douglas B.
A1 Tsai, Susan
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145764665
T1 Molecular Genetics of Pancreatic Neoplasms and Inherited Pancreatic Cancer Syndromes
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145764665
RD 2024/04/19
AB Cancer  is  fundamentally  a  genetic  disease  that  develops  when  alterations  in  multiple  genes  result  in  dysregulation  of  a  select  number  of  cellular  pathways  and  processes.  In  the  last  decade,  rapid  advances  in  nucleotide  sequencing  and  bioinformatic  technology  have  led  to  an  expansion  of  information  obtained  from  the  sequencing  of  cancer  genomes.  Sequencing  of  pancreatic  cancer  (PC)  genomes  as  well  as  premalignant  lesions  of  the  pancreas  has  deepened  our  understanding  of  tumorigenesis  and  identified  potential  novel  therapeutic  targets.  Although  PC  has  generally  been  associated  with  acquired  genetic  mutations,  a  small  proportion  of  PCs  may  be  due  to  inherited  PC  syndromes.  In  this  chapter,  we  focus  on  the  current  understanding  of  proposed  critical  genes  and  affected  pathways  that  have  been  shown  to  be  important  in  sporadic  and  hereditary  PCs.