RT Book, Section
A1 Catterall, William A.
A1 Mackie, Kenneth
A2 Brunton, Laurence L.
A2 Hilal-Dandan, Randa
A2 Knollmann, Björn C.
SR Print(0)
ID 1162537072
T1 Local Anesthetics
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259584732
LK hemonc.mhmedical.com/content.aspx?aid=1162537072
RD 2024/04/18
AB Local  anesthetics  bind  reversibly  to  a  specific  receptor  site  within  the  pore  of  the  Na+  channels  in  nerves  and  block  ion  movement  through  this  pore.  When  applied  locally  to  nerve  tissue  in  appropriate  concentrations,  local  anesthetics  can  act  on  any  part  of  the  nervous  system  and  on  every  type  of  nerve  fiber,  reversibly  blocking  the  action  potentials  responsible  for  nerve  conduction.  Thus,  a  local  anesthetic  in  contact  with  a  nerve  trunk  can  cause  both  sensory  and  motor  paralysis  in  the  area  innervated.  These  effects  of  clinically  relevant  concentrations  of  local  anesthetics  are  reversible  with  recovery  of  nerve  function  and  no  evidence  of  damage  to  nerve  fibers  or  cells  in  most  clinical  applications.