RT Book, Section
A1 Krensky, Alan M.
A1 Azzi, Jamil R.
A1 Hafler, David A.
A2 Brunton, Laurence L.
A2 Hilal-Dandan, Randa
A2 Knollmann, Björn C.
SR Print(0)
ID 1162539782
T1 Immunosuppressants and Tolerogens
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259584732
LK hemonc.mhmedical.com/content.aspx?aid=1162539782
RD 2024/04/18
AB This  chapter  reviews  the  components  of  the  immune  response  and  drugs  that  modulate  immunity  via  immunosuppression  or  tolerance.  Four  major  classes  of  immunosuppressive  drugs  are  discussed:  glucocorticoids  (see  Chapter  46),  calcineurin  inhibitors,  antiproliferative  and  antimetabolic  agents  (see  Chapter  66),  and  antibodies.  While  there  are  similarities,  the  approach  to  the  use  of  immunosuppressant  drugs  in  transplant  rejection  has  evolved  separately  from  the  approaches  used  to  treat  autoimmune  disease  and  thus  is  presented  separately.  Finally,  the  chapter  ends  with  a  brief  case  study  of  immunotherapy  for  the  autoimmune  disease  MS.