RT Book, Section A1 Press, Oliver W. A1 Lichtman, Marshall A. A1 Leonard, John P. SR Print(0) ID 1148367598 T1 Preface T2 Williams Hematology Malignant Lymphoid Diseases YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781260117066 LK hemonc.mhmedical.com/content.aspx?aid=1148367598 RD 2024/03/28 AB Bifurcation is an essential feature of biology. It underlies differentiation as one cell, through a process of mitosis accompanied by altered gene expression, forms two distinct cell lineages. The hematopoietic system is a dramatic example of this phenomenon. A single lymphohematopoietic stem cell, can over the course of several bifurcations, differentiate and then mature into at least 11 unique functional cells. In some cases, these cells can mature further into different phenotypes influenced by the environment in which they reside. Consider, for example, the monocytes, Kupffer cells, osteoclasts, microglia, and alveolar macrophages.