RT Book, Section A1 Diz-Küçükkaya, Reyhan A1 López, José A. A2 Kaushansky, Kenneth A2 Levi, Marcel SR Print(0) ID 1148371772 T1 Thrombocytopenia T2 Williams Hematology Hemostasis and Thrombosis YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781260117080 LK hemonc.mhmedical.com/content.aspx?aid=1148371772 RD 2024/10/07 AB SUMMARYThrombocytopenia is one of the most frequent causes for hematologic consultation in the practice of medicine and may be life threatening. Although the normal platelet count in humans (150 to 400 × 109/L) far exceeds the minimal level required to avoid pathologic hemorrhage (<50 × 109/L), a number of medical conditions either increasing the destruction of platelets or reducing their production enhance the risk of bleeding. This chapter discusses an approach to the diagnosis of thrombocytopenia, grouping various causes by mechanism of action, and describing our current understanding of the pathogenesis, treatment, and prognosis. In the vast majority of patients, a cause for thrombocytopenia can be identified and effective therapy instituted.