RT Book, Section
A1 Trinchieri, Giorgio
A1 Childs, Richard W.
A1 Lanier, Lewis L.
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178737619
T1 The Biology of Innate Lymphoid Cells and Natural Killer Cells
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1178737619
RD 2024/04/18
AB SUMMARYInnate  lymphoid  cells  (ILCs)  are  a  distinct  lineage  of  lymphocytes  that  differ  from  immune  lymphoid  cells  by  not  expressing  somatically  rearranged  genes  encoding  antigen  specific  receptors.  They  are  important  in  maintaining  the  homeostasis  of  different  tissues  and  they  have  been  classified  into  group  1,  2,  and  3  based  on  their  homology  in  functions  and  cytokine  production  with  the  T-helper  subsets  Th1,  Th2,  and  Th22/17,  respectively.  Natural  killer  (NK)  cells  are  now  considered  to  belong  to  group  1  ILCS.  NK  cells  have  a  constitutive  ability  to  mediate  cytotoxicity  of  pathologic  target  cells  and  to  secrete  cytokines,  participate  in  the  innate  resistance  to  intracellular  pathogens  and  malignancies,  and  have  a  modulatory  effect  on  adaptive  immunity  and  hematopoiesis.  NK  cell  activity  is  regulated  by  the  opposite  effects  of  activating  and  inhibitory  receptors.