RT Book, Section
A1 Turhan, Ali G.
A1 Bennaceur-Griscelli, Annelise
A1 Eaves, Connie J.
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178738055
T1 Regenerative Medicine: Induced Pluripotent Stem Cells And Blood Cell Engineering
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1178738055
RD 2024/04/25
AB SUMMARYThe  first  two  decades  of  the  21st  century  have  shown  major  breakthroughs  in  the  development  of  protocols  for  generating  human  hematopoietic  cells  ex  vivo  and  for  engineering  them  genetically.  These  breakthroughs  have  come  from  the  discovery  that  immortal  lines  of  pluripotent  cells,  very  similar  to  embryonic  stem  cells  and  capable  of  generating  cells  of  all  tissues,  can  be  readily  derived  from  many  types  of  mature  human  cells.  Also  significant  has  been  the  development  of  strategies  for  targeting  genetic  changes  in  genomic  DNA  with  unprecedented  specificity  and  efficiency.  These  findings  make  it  possible  to  analyze  and  manipulate  previously  inaccessible  stages  of  human  tissue  development  and  human  disease  processes.  These  capabilities  have  also  sparked  the  pursuit  of  new  systems  for  testing  novel  treatments  that  were  recently  seen  as  “pipe  dreams.”  Together,  the  promise  afforded  these  initial,  but  seminal,  advances  has  changed  our  appreciation  of  the  future  landscape  of  general  regenerative  medicine  and  for  hematologic  diseases  in  particular.