RT Book, Section
A1 Weinstein, Robert
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178738739
T1 Therapeutic Apheresis: Indications, Efficacy, and Complications
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1178738739
RD 2024/04/24
AB SUMMARYTherapeutic  apheresis  refers  to  several  blood  processing  methods  that  are  used  in  the  treatment  of  diverse  clinical  conditions.  In  most  cases,  the  disorders  so  treated  are  characterized  by  a  specific  qualitative  or  quantitative  abnormality  of  the  blood.  In  hematologic  practice,  apheresis  procedures  are  used  to  mitigate  hyperviscosity  in  monoclonal  protein  disorders  or  remove  pathologic  autoantibodies  and  replete  important  plasma  proteins.  Red-cell  apheresis  is  used  to  improve  the  ratio  of  normal  to  abnormal  red  cells  in  hemoglobinopathies  and  protozoan  disease,  and  to  remove  excess  red  cells,  red  cell–associated  toxins,  or  excess  iron  from  the  body.  Leukocyte  apheresis  is  used  to  reduce  the  circulating  blast  count  in  acute  leukemias  with  hyperleukocytosis,  and  platelet  apheresis  is  used  to  lower  a  very  elevated  platelet  count  in  patients  with  myeloproliferative  neoplasms.  Photopheresis  is  used  in  the  treatment  of  cutaneous  T-cell  lymphoma  and  chronic  graft-versus-host  disease.  Adverse  effects  of  apheresis  with  current  technologies  are  typically  mild  and  usually  do  not  prevent  completion  of  therapy.