RT Book, Section
A1 Seet, Christopher S.
A1 Crooks, Gay M.
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178749218
T1 Lymphopoiesis
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1178749218
RD 2024/04/25
AB SUMMARYLymphopoiesis  refers  to  the  process  by  which  the  lymphoid  components  of  the  adaptive  and  innate  immune  systems  are  produced  during  hematopoietic  differentiation.  This  process  begins  with  the  hematopoietic  stem  cell  and  continues  through  progenitor  stages  down  a  series  of  mostly  diverging  lineage  pathways,  ultimately  resulting  in  the  remarkable  diversity  and  flexibility  of  the  immune  system.  Although  the  more  terminal  events  in  lymphocyte  differentiation  and  function  have  been  defined  in  detail  (Chaps.  20,  21,  75,  76),  the  earliest  events  during  which  hematopoietic  stem  cells  undergo  lymphoid  lineage  commitment  are  less  well  understood  and  still  controversial.  Although  the  conceptual  framework  for  the  questions  of  lymphoid  commitment  has  been  established  largely  on  studies  in  the  mouse,  experimental  systems  now  exist  to  better  understand  how  such  events  are  controlled  in  humans.  This  chapter  summarizes  what  is  known  about  the  ontogeny  of  lymphoid  development  and  the  control  of  lymphoid  differentiation,  and  it  discusses  some  of  the  persisting  controversies  in  the  field.