RT Book, Section
A1 Alexandrescu, Doru T.
A1 Levi, Marcel
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178754889
T1 The Vascular Purpuras
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1178754889
RD 2024/04/16
AB SUMMARYPurpura,  the  clinical  manifestation  of  blood  extravasation  into  mucosa  or  skin,  results  from  various  conditions,  including  rheumatologic,  infectious,  dermatologic,  traumatic,  and  hematologic  disorders.  This  chapter  does  not  detail  purpura  resulting  from  quantitative  or  functional  defects  in  hemostasis  and  coagulation,  such  as  deficiencies  of  platelets  or  coagulation  factors;  these  causes  are  discussed  in  other  chapters  (eg,  thrombocytopenia  in  Chap.  116,  coagulation  factor  deficiencies  in  Chaps.  122  and  123).The  differential  diagnosis  of  the  disparate  causes  of  noncoagulopathic  purpura  is  best  approached  by  stratifying  purpura  into  three  types  of  lesions:  (1)  palpable  or  retiform  and  noninflammatory,  such  as  hyperglobulinemic  purpura  of  Waldenström;  (2)  palpable  or  nonpalpable  but  inflammatory,  such  as  Henoch-Schönlein  purpura;  and  (3)  nonpalpable  and  noninflammatory,  such  as  senile  purpura.  By  accounting  for  palpability,  presence  of  inflammation,  size,  and  shape,  the  differential  diagnosis  of  a  particular  lesion  can  be  significantly  reduced.