RT Book, Section
A1 Aung, Kyaw Lwin
A1 Zhou, Stanley
A1 Lupien, Mathieu
A2 Harrington, Lea A.
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Cescon, David W.
SR Print(0)
ID 1179323352
T1 Epigenetics
T2 The Basic Science of Oncology, 6e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781259862076
LK hemonc.mhmedical.com/content.aspx?aid=1179323352
RD 2024/04/24
AB The  human  genome  found  in  each  cell  of  the  body  consists  of  ~6  billion  bases  of  DNA  forming  a  sequence  unique  to  each  individual.  This  sequence  contributes  to  differences  in  phenotypic  traits  among  individuals,  such  as  height,  as  well  as  risks  of  developing  different  diseases.  However,  the  DNA  sequence  alone  cannot  account  for  the  phenotypic  identity  that  discriminates  between  different  cell  types  and  tissues  of  a  human  being,  because  (with  few  exceptions)  the  DNA  sequence  is  largely  identical  in  each  cell.  Thus,  cell  type–specific  gene  expression  programs  require  an  additional  system  of  control  to  achieve  this  phenotypic  diversity,  a  system  commonly  referred  to  as  epigenetics.