RT Book, Section
A1 Harrington, Lea A.
A2 Harrington, Lea A.
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Cescon, David W.
SR Print(0)
ID 1179323755
T1 Cellular Signaling
T2 The Basic Science of Oncology, 6e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781259862076
LK hemonc.mhmedical.com/content.aspx?aid=1179323755
RD 2024/04/19
AB The  perturbation  and  conscription  of  normal  cellular  signaling  processes  is  one  of  the  defining  features  in  the  development  of  cancer  (Hanahan  and  Weinberg,  2011).  A  major  challenge  in  the  development  of  therapeutics  against  signaling  networks  is  the  ability  to  target  these  perturbations  without  interfering  with  the  ability  of  normal  cells  and  tissues  to  receive  and  respond  to  extracellular  signals.  The  ability  to  respond  to  extracellular  signals  is  essential  to  our  ability  to  respond  to  our  physical  or  chemical  environment,  and  to  initiate  the  necessary  modifications  of  cell  metabolism,  morphology,  movement,  and  proliferation.  These  responses  are  brought  about  by  elaborate  networks  of  intracellular  signals  transmitted  by  changes  in  protein  phosphorylation  and  enzymatic  activity,  localization,  and  the  formation  of  protein-protein  complexes.  In  turn,  cellular  responses  are  triggered  by  the  recognition  of  extracellular  signals  at  the  cell  surface,  resulting  in  the  activation  of  cytoplasmic  enzymes  that  trigger  biochemical  cascades  in  the  cytoplasm  and  nucleus.  These  signal  transduction  networks  are  critical  to  numerous  cellular  processes  that  range  from  the  generalized  control  of  cell  proliferation  and  survival,  to  specialized  functions  such  as  the  immune  response  and  angiogenesis.  This  chapter  will  focus  on  how  the  dysregulation  of  networks  involved  in  normal  growth,  adhesion,  and  development  contribute  to  malignant  transformation  in  human  cells,  and  how  these  perturbations  can  be  exploited  to  develop  new  cancer  therapeutics.