RT Book, Section A1 Dhani, Neesha A1 Hill, Richard P. A1 Tannock, Ian F. A2 Harrington, Lea A. A2 Tannock, Ian F. A2 Hill, Richard P. A2 Cescon, David W. SR Print(0) ID 1179324690 T1 Tumor Growth, Microenvironment, Metabolism, and Hypoxia T2 The Basic Science of Oncology, 6e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781259862076 LK hemonc.mhmedical.com/content.aspx?aid=1179324690 RD 2024/03/29 AB Tumors grow because the homeostatic mechanisms that maintain the appropriate number of cells in normal tissues are defective, leading to an imbalance between cell proliferation and cell death and to expansion of the cell population. Methods based on autoradiography with tritiated thymidine in the 1950s and 1960s, and the subsequent application of flow cytometry, have allowed a detailed analysis of tumor growth in terms of the kinetics of proliferation of the constituent cells. The proliferative rate of tumor cells varies widely between tumors; slowly proliferating or nonproliferating cells are common, and there is often a high rate of cell death.