RT Book, Section
A1 Hebbel, Robert P.
A1 Belcher, John D.
A1 Vercellotti, Gregory M.
A2 Gladwin, Mark T.
A2 Kato, Gregory J.
A2 Novelli, Enrico M.
SR Print(0)
ID 1179338362
T1 Ischemia-Reperfusion Pathobiology in Sickle Cell Anemia
T2 Sickle Cell Disease
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260458596
LK hemonc.mhmedical.com/content.aspx?aid=1179338362
RD 2024/04/23
AB The  polymerization  of  deoxygenated  sickle  hemoglobin  provides  the  elemental  basis  for  the  pathophysiology  of  sickle  cell  anemia  (SCA).  Nonetheless,  this  disease  still  presents  abundant  uncertainties  and  mysteries,  something  particularly  true  for  events  involved  in  the  occurrence,  resolution,  and  consequences  of  sickle  vaso-occlusion.1  This  chapter  will  describe  the  unique  character  of  ischemia-reperfusion  (I/R)  pathophysiology  occurring  in  SCA  and  why  it  likely  plays  a  pivotal  role  in  its  pathophysiology.  Indeed,  some  features  of  SCA  are  less  easily  explained,  in  particular  the  perpetuity,  intensity,  systematicity,  complexity,  and  instability  of  its  unique  inflammatory  state.2-4