RT Book, Section A1 Shilo, Natalie R. A1 Klings, Elizabeth S. A1 Morris, Claudia R. A2 Gladwin, Mark T. A2 Kato, Gregory J. A2 Novelli, Enrico M. SR Print(0) ID 1179343325 T1 The Asthma Conundrum in Sickle Cell Disease T2 Sickle Cell Disease YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260458596 LK hemonc.mhmedical.com/content.aspx?aid=1179343325 RD 2024/10/08 AB A comorbid diagnosis of asthma is a negative prognostic factor for patients with sickle cell disease (SCD). It is associated with increased frequency of acute chest syndrome (ACS) episodes in children and adolescents, progression of disease, and an increased mortality rate.1-8 Given these findings, the concept of asthma as a modifiable risk factor in SCD developed.3 Simply making an earlier diagnosis of asthma seemed to be an opportunity by which to significantly improve outcomes in SCD. It turns out that the pathophysiology, diagnosis, and treatment of asthma in individuals with SCD is far from straightforward, but recognizing and treating the airway disease in individuals with SCD remains crucial to improving patient outcomes.