RT Book, Section
A1 Sachdev, Vandana
A1 Malik, Punam
A1 Wood, John
A1 Detterich, Jon
A2 Gladwin, Mark T.
A2 Kato, Gregory J.
A2 Novelli, Enrico M.
SR Print(0)
ID 1179344262
T1 Cardiac Complications
T2 Sickle Cell Disease
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260458596
LK hemonc.mhmedical.com/content.aspx?aid=1179344262
RD 2024/09/16
AB The  heart,  lungs,  and  blood  vessels  represent  an  integrally  coupled  system.  Sickle  cell  disease  (SCD)  is  characterized  by  a  diffuse,  progressive  vascular  disease  that  not  only  directly  damages  cardiac  microvasculature  but  also  places  abnormal  mechanical  stressors  on  the  heart  by  increasing  preload  (anemia)  and  afterload  (peripheral  and  pulmonary  vascular  damage).  The  heart  may  also  be  damaged  by  the  sequelae  of  treatments  for  SCD,  such  as  chronic  transfusions.  In  this  section,  we  focus  on  how  the  primary  vascular  physiology  described  in  earlier  sections  impacts  the  integrated  cardiovascular  system.