RT Book, Section A1 Wang, Winfred C. A1 Ware, Russell E. A2 Gladwin, Mark T. A2 Kato, Gregory J. A2 Novelli, Enrico M. SR Print(0) ID 1179345686 T1 Hydroxyurea and Sickle Cell Disease T2 Sickle Cell Disease YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260458596 LK hemonc.mhmedical.com/content.aspx?aid=1179345686 RD 2024/03/28 AB Landmark natural history studies, including the Cooperative Study of Sickle Cell Disease1 and the Jamaican Cohort Study,2 generated the seminal observations that fetal hemoglobin (HbF) is a critically important laboratory parameter for individuals with sickle cell anemia (SCA). Higher HbF levels are associated with better clinical outcomes including reduced mortality,3-5 and if present at sufficient levels with pancellular distribution, higher HbF levels can lead to a benign condition.6