RT Book, Section A1 Lomas-Francis, Christine A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180471162 T1 Erythrocyte Antigens and Antibodies T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK hemonc.mhmedical.com/content.aspx?aid=1180471162 RD 2024/03/28 AB SUMMARYBlood group antigens are structures on the outer surface of human red blood cells (RBCs) that can be recognized by the immune system of individuals who lack that particular structure. Identification of RBC antigens and antibodies is the basis of pretransfusion compatibility testing and the safe transfusion practices used today and provides insights into understanding the etiology of hemolytic disease of the fetus and the newborn. Biochemical and molecular studies have led to definition of the biologic functions of molecules expressing blood group antigens. These molecules play a critical role in susceptibility to infection by malarial parasites, some viruses, and bacteria. Alteration of RBC antigen expression is associated with many molecular backgrounds, and some play a role in the clinical manifestations of certain diseases. Erythrocytes, far from being inert containers of hemoglobin, are active in a variety of physiologic processes.