RT Book, Section A1 Levy, Jerrold H. A1 Shaz, Beth A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180471680 T1 Using Plasma and Plasma Component Therapy T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK hemonc.mhmedical.com/content.aspx?aid=1180471680 RD 2024/03/29 AB SUMMARYPlasma and plasma component therapy includes fresh frozen plasma, plasma, and cryoprecipitate. Although plasma is used extensively in many clinical applications that include coagulopathy and coagulation factor correction and surgical and traumatic bleeding resuscitation, data supporting its efficacy are limited. Plasma-based transfusions also pose multiple risks, including circulatory overload and transfusion-related acute lung injury. Indications for plasma and cryoprecipitate vary between countries, and the use of factor concentrates including prothrombin complex concentrates and fibrinogen are increasingly used as potential replacements. Strategies are available for pathogen reduction for plasma and plasma products, but additional cost and loss of factors are considerations for their use.