RT Book, Section
A1 Kaushansky, Kenneth
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1180477309
T1 Signal Transduction Pathways
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1180477309
RD 2024/04/24
AB SUMMARYMost  external  influences  on  cells  of  any  organ  are  mediated  by  biochemical  and  molecular  mechanisms  that  are  triggered  by  interactions  with  membrane,  cytoplasmic,  or  nuclear  receptors.  Our  understanding  of  the  receptors  and  the  intermediate  molecules  that  couple  them  with  cellular  pathways  that  influence  the  proliferation,  activation,  differentiation,  or  survival  of  hematopoietic  cells  has  expanded  significantly.  Proteins  on  the  surface  of  blood  cells  that  transmit  vital  information  from  the  extracellular  environment  include  (a)  single-pass,  homodimeric,  heterodimeric,  and  heterotrimeric  transmembrane  proteins  that  do  or  do  not  contain  intrinsic  kinase  activity  but  either  way  signal  by  inducing  the  tyrosine  phosphorylation  of  a  multitude  of  cytoplasmic  proteins;  (b)  seven  transmembrane  domain  proteins  that  signal  through  G  proteins;  (c)  heterodimeric  integrins  that  recruit  large  focal  adhesions;  (d)  large  families  of  heterodimeric  proteins  that  induce  serine  and  threonine  phosphorylation;  and  (e)  a  number  of  incompletely  understood  external  influences  such  as  neural  signals,  bacterial  products,  and  lipids.  This  chapter  describes  the  receptors  that  influence  blood  cell  production  and  function,  the  secondary  mediators  and  the  biochemical  modifications  they  undergo  to  alert  the  cell  to  an  external  influence,  the  molecular  mechanisms  that  allow  for  the  coordination  of  multiple  signals  impacting  a  cell  simultaneously,  and  the  processes  on  which  they  impact.