RT Book, Section
A1 Alatrash, Gheath
A1 Molldrem, Jeffrey J.
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1180478048
T1 Vaccine Therapy
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK hemonc.mhmedical.com/content.aspx?aid=1180478048
RD 2024/04/24
AB SUMMARYVaccines  are  biologic  substances  that  are  designed  to  stimulate  the  host  immune  system  to  elicit  a  neutralizing  response  against  clinically  relevant  targets,  including  pathogens  and  tumors.  Active  immunotherapy  with  vaccines  has  been  extremely  effective  as  prevention  against  infectious  pathogens.  However,  effective  vaccine  therapy  of  chronic  infectious  diseases  or  cancer,  in  the  therapeutic  setting,  remains  a  promising  but  largely  unrealized  goal.  Hematologic  malignancies  are  an  excellent  model  system  for  vaccine  therapies,  in  part  because  of  accessibility  to  the  hematopoietic  and  lymphatic  tissue,  tumor  susceptibility  to  immune  effector  mechanisms,  and  availability  of  tumor  cells  for  mechanistic  studies.