RT Book, Section A1 Fung, Monica A1 Babik, Jennifer A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180478965 T1 Treatment of Infections in the Immunocompromised Host T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK hemonc.mhmedical.com/content.aspx?aid=1180478965 RD 2024/03/28 AB SUMMARYInfection is a major cause of morbidity and mortality in patients with severe inherited or acquired neutropenia or aplastic anemia, qualitative disorders of neutrophils, and, notably, persons receiving chemotherapy for treatment of hematologic neoplasms. Severe neutropenia and monocytopenia often result from the combined effects of replacement of marrow with malignant cells and superimposed intense chemotherapy. The severity and duration of the neutropenia determine the risk of infection. Bacterial infections may result in rapid clinical deterioration and even death. Fungal and viral infections also may result in potentially lethal complications during or after chemotherapy. This chapter considers methods of diagnosis of bacterial, fungal, and viral infections and describes treatment regimens. Because prevention of infection during periods of neutropenia can reduce morbidity and improve outcome, attention is focused on prophylaxis strategies against bacterial, viral, and fungal infections.