RT Book, Section A1 Dimopoulos, Christina A1 Llor, Xavier A2 Llor, Xavier A2 Hofstatter, Erin Wysong SR Print(0) ID 1182365654 T1 Hereditary Nonpolyposis Colorectal Cancers T2 Cancer Genetics: A Clinical Approach YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781260440270 LK hemonc.mhmedical.com/content.aspx?aid=1182365654 RD 2024/03/28 AB Hereditary colorectal cancers, both polyposis and nonpolyposis, arise from either high-penetrance germline mutations (such as in mismatch repair genes causing Lynch syndrome), moderate-penetrance genes (such as CHEK2 or the APC I1307 variant), and low-penetrance alleles. Nevertheless, in a significant number of cases that are highly suspicious for being hereditary, no pathogenic variants are identified in the known susceptibility genes.