RT Book, Section A1 Gregg, Xylina T. A2 Prchal, Josef T. A2 Lichtman, Marshall A. SR Print(0) ID 1184010369 T1 Erythropoietic Effects of Endocrine Disorders T2 Williams Hematology The Red Cell and Its Diseases YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781264269075 LK hemonc.mhmedical.com/content.aspx?aid=1184010369 RD 2024/03/28 AB SUMMARYThe endocrine system influences homeostasis of virtually every tissue. Thus, it is not unexpected that it also influences hematopoiesis. However, the effect of endocrine disequilibrium is principally on erythropoiesis with limited impact on leukocytes, platelets, and hemostasis. Thus, anemia is the most common hematopoietic abnormality in endocrine disorders and may be the first manifestation of an endocrine disorder. Erythrocytosis is less common but occurs in certain endocrine disorders (eg, congenital adrenal hyperplasia, pheochromocytoma). The pathophysiologic basis of the anemia is often multifactorial, but a direct influence of hormones on erythropoiesis in some instances may contribute to anemia. A decreased plasma volume in some of these disorders may mask the severity of anemia. Some endocrine disorders are associated with an impaired response to the therapeutic use of erythropoietin.