RT Book, Section
A1 Reddy, Vishnu V.B.
A1 Morlote, Diana
A2 Prchal, Josef T.
A2 Lichtman, Marshall A.
SR Print(0)
ID 1184011315
T1 Anemia Associated with Marrow Infiltration
T2 Williams Hematology The Red Cell and Its Diseases
YR 2022
FD 2022
PB McGraw Hill
PP New York, NY
SN 9781264269075
LK hemonc.mhmedical.com/content.aspx?aid=1184011315
RD 2023/09/22
AB SUMMARYMyelophthisic  anemia  is  caused  by  marrow  infiltration,  typically  by  metastatic  cancer  but  also  by  any  nonhematopoietic  conditions  such  as  granulomatous  inflammation  or  fibrosis.  It  can  present  with  an  overt  leukoerythroblastic  picture  or  with  only  a  few  teardrop-shaped  red  cells  on  a  blood  film.  These  changes  may  represent  an  early  spread  of  the  tumor  (or  other  nonhematopoietic  entities)  to  the  marrow  or  may  indicate  massive  replacement  of  the  marrow  space.  The  diagnosis  can  be  made  by  standard  marrow  biopsy.  Radioisotope  scanning,  positron  emission  tomography/computed  tomography  (PET/CT),  and  magnetic  resonance  imaging  (MRI),  although  not  very  sensitive,  can  be  helpful  in  locating  the  biopsy  site  and  can  also  help  estimating  the  percentage  of  involvement  of  the  marrow  space.