RT Book, Section A1 Lomas-Francis, Christine A2 Prchal, Josef T. A2 Lichtman, Marshall A. SR Print(0) ID 1184014097 T1 Erythrocyte Antigens and Antibodies T2 Williams Hematology The Red Cell and Its Diseases YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781264269075 LK hemonc.mhmedical.com/content.aspx?aid=1184014097 RD 2024/03/28 AB SUMMARYBlood group antigens are structures on the outer surface of human red blood cells (RBCs) that can be recognized by the immune system of individuals who lack that particular structure. Identification of RBC antigens and antibodies is the basis of pretransfusion compatibility testing and the safe transfusion practices used today and provides insights into understanding the etiology of hemolytic disease of the fetus and the newborn. Biochemical and molecular studies have led to definition of the biologic functions of molecules expressing blood group antigens. These molecules play a critical role in susceptibility to infection by malarial parasites, some viruses, and bacteria. Alteration of RBC antigen expression is associated with many molecular backgrounds, and some play a role in the clinical manifestations of certain diseases. Erythrocytes, far from being inert containers of hemoglobin, are active in a variety of physiologic processes.