RT Book, Section
A1 Rafei, Hind
A1 Olson, Amanda
A1 Mehta, Rohtesh S.
A1 Oran, Betul
A1 Rezvani, Katayoun
A1 Shpall, Elizabeth J.
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
A2 Rieber, Alyssa G.
SR Print(0)
ID 1190834033
T1 Alternative Donor Transplants: Cord Blood Transplant
T2 The MD Anderson Manual of Medical Oncology, 4e
YR 2022
FD 2022
PB McGraw Hill Education
PP New York, NY
SN 9781260467642
LK hemonc.mhmedical.com/content.aspx?aid=1190834033
RD 2024/04/19
AB KEY  CONCEPTSCord  blood  is  a  valuable  alternative  donor  source  for  stem  cell  transplant,  offering  a  number  of  advantages:  ease  of  collection,  availability  for  urgent  need,  less  stringent  human  leukocyte  antigen  (HLA)-matching  requirement,  and  lower  risk  of  graft-versus-host  disease.Data  are  evolving  about  the  difference  in  outcomes  of  stem  cell  transplant  using  different  graft  sources,  but  more  recent  data  suggest  that  there  is  no  survival  advantage  of  a  matched  unrelated  graft  over  cord  blood.To  overcome  the  limitation  of  low  cell  doses  in  single  cord  blood  units,  double  cord  blood  transplant  has  been  adopted  for  many  patients.High-intensity  myeloablative  regimens  are  used  in  young  and  fit  patients,  whereas  reduced-intensity  regimens  are  used  in  older  or  unfit  patients.Infections  are  the  leading  cause  of  early  nonrelapse  mortality  after  cord  blood  transplant,  and  graft-versus-host  disease  is  the  leading  cause  of  late  mortality.Novel  strategies  to  improve  cord  blood  transplant  outcomes  include  improving  cell  collection,  homing  and  engraftment,  ex  vivo  expansion,  and  in  vivo  enhancement.