RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189333342
T1 Methemoglobinemia and Other Dyshemoglobinemias
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189333342
RD 2024/09/13
AB Increased  methemoglobin  from  a  baseline  of  less  than  1%  occurs  due  to  oxidation  of  ferro  to  ferric  iron  of  hemoglobin  due  to  environmental  agents  or  due  to  underlying  germline  mutations  causing  diminished  reduction  of  methemoglobin  to  hemoglobin.  Cyanosis  is  seen  when  total  methemoglobin  exceeds  15  g/L;  thus,  at  10%  of  methemoglobin,  those  with  hemoglobin  concentrations  above  150  g/L  would  have  cyanosis,  whereas  those  with  hemoglobin  below  150  g/L  would  not.Dyshemoglobinemia  is  a  term  used  for  modified  hemoglobins  (eg,  methemoglobin,  carboxyhemoglobin,  nitrosohemoglobin,  and  sulfhemoglobin)  that  are  associated  with  normal  amino  acid  sequence  of  hemoglobin  tetramers;  however,  in  M  hemoglobins,  the  globins  are  mutated  changing  amino  acid  in  hemoglobin  tetramers.  They  can  result  in  varying  degrees  of  clinical  manifestations.