RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189333498
T1 Hemolytic Anemia Resulting from Warm-Reacting Antibodies
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189333498
RD 2024/04/25
AB In  autoimmune  hemolytic  anemia  (AHA),  shortened  red  cell  survival  is  the  result  of  host  antibodies  that  react  with  autologous  red  cells.AHA  may  be  classified  by  whether  an  underlying  disease  is  present  (secondary)  or  not  (primary  or  idiopathic)  (Table  22–1).AHA  may  also  be  classified  by  the  nature  of  the  antibody  (Table  22–2).“Warm-reacting”  antibodies  are  usually  of  the  immunoglobulin  G  (IgG)  type,  have  optimal  activity  at  37°C,  and  bind  complement.“Cold-reacting”  antibodies  show  affinity  at  lower  temperatures  (see  Chap.  23).Occasionally,  mixed  disorders  occur  with  both  warm  and  cold  antibodies.Warm-antibody  AHA  is  the  most  common  type.