RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189334109
T1 Inflammatory and Malignant Histiocytosis
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189334109
RD 2024/04/19
AB Histiocyte  is  an  archaic  term  for  macrophages.  The  histiocytoses  include  diseases  arising  from  all  cells  of  the  mononuclear  phagocytic  system,  with  diseases  characterized  by  presumed  lineage  and  biology  into  dendritic  cell  (DC)  disorders,  macrophage-related  disorders,  and  malignant  histiocytic  disorders  (Table  36–1).Historically,  the  histiocytic  disorders  have  been  characterized  by  the  phenotype  of  disease-specific  histiocytes  (Table  36–2).Now,  recurrent  mitogen-activated  protein  kinase  (MAPK)  pathway  mutations  in  clonal  myeloid  cells  in  Langerhans  cell  histiocytosis  (LCH),  Erdheim-Chester  disease  (ECD),  juvenile  xanthogranuloma  (JXG),  Rosai-Dorfman  disease  (RDD),  and  malignant  histiocytic  diseases  clearly  separate  these  neoplastic  diseases  of  inflammatory  cells  from  hemophagocytic  lymphohistiocytosis  (HLH),  characterized  by  polyclonal  reactive  macrophages.