RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Linch, David C. SR Print(0) ID 1189334615 T1 The Acute Myelogenous Leukemias T2 Williams Manual of Hematology, 10e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269204 LK hemonc.mhmedical.com/content.aspx?aid=1189334615 RD 2024/03/29 AB Acute myelogenous leukemia (AML) is a malignancy originating in the lymphohematopoietic stem cell or a closely related multipotential hematopoietic cell.It is characterized by clonal proliferation of leukemic blast cells in the marrow and impaired production of normal blood cells, resulting in anemia; thrombocytopenia; and low, normal, or high white cell counts depending on the concentration of leukemic cells in the blood.AML occurs in nine morphologic (phenotypic) variants, each with characteristic cytologic, genetic, and sometimes clinical features.It has been found to have innumerable (>150) mutated genetic driver and cooperating oncogenes.