RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189335445
T1 Hodgkin Lymphoma
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189335445
RD 2024/09/16
AB Hodgkin  lymphoma  (HL)  is  a  lymphoid  neoplasm  consisting  of  two  distinct  entities:  classic  Hodgkin  lymphoma  (cHL),  accounting  for  95%  of  cases,  and  nodular  lymphocyte-predominant  Hodgkin  lymphoma  (NLPHL),  accounting  for  about  5%  of  cases.Both  types  of  HL  are  derived  from  germinal  center  B  cells.cHL  is  defined  by  the  presence  of  the  Reed-Sternberg  (RS)  cells  or  its  mononuclear  variant  Hodgkin  cells  with  a  characteristic  immunophenotype  and  appropriate  cellular  background  (Figures  60–1  and  60–2).The  neoplastic  cells  account  for  only  1%  to  5%  of  cells  in  an  affected  node  or  tissue.HL  cells  secrete  cytokines  and  chemokines,  which  attract  multiple  reactive  cell  types,  with  T  cells  predominating.  The  survival  of  HL  cells  is  dependent  on  these  cells  in  the  microenvironment.cHL  consists  of  four  histologic  subtypes  that  are  distinguished  based  on  microscopic  appearance  and  relative  proportions  of  RS  cells,  lymphocytes,  and  fibrosis:—  Nodular  sclerosis  (~60%–65%  of  cases)  predominates  in  young  adults.  The  RS  cells  appear  as  lacunar  cells.—  Mixed  cellularity  (~25%–35%  of  cases)  predominates  in  older  adults.—  Lymphocyte-rich  (~5%  of  cases)  is  most  frequent  in  males.—  Lymphocyte-depleted  is  very  rare.The  malignant  cells  in  NLPHL  are  called  lymphocytic/histiocytic  cells  or  “popcorn”  cells  and  are  embedded  in  B-cell–rich  nodules.The  distinguishing  pathologic  features  between  cHL  and  NLPHL  are  shown  in  Table  60–1.