RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189335601
T1 Marginal Zone B-Cell Lymphoma
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189335601
RD 2023/03/22
AB The  marginal  zone  lymphomas  (MZLs)  are  derived  from  memory-type  or  antigen-experienced  B  cells  that  reside  in  regions  contiguous  to  the  outer  part  of  the  mantle  zones  of  B-cell  folliclesMZL  cells  are  usually  small  to  medium-sized  lymphocytes  with  irregularly  shaped  nuclei  with  dispersed  chromatin  and  inconspicuous  nucleoli.The  World  Health  Organization  (WHO)  defines  three  separate  MZL  entities,  namely,  the  extranodal  marginal  zone  B-cell  lymphoma  of  mucosa-associated  lymphoid  tissue  (known  as  MALT  lymphoma)  (70%),  the  splenic  marginal  zone  B-cell  lymphoma  (SMZL)  (20%),  and  the  nodal  marginal  zone  B-cell  lymphoma  (NMZL)  (<10%).Lymphoepithelial  lesions  characterized  by  invasion  or  necrotic  destruction  of  the  glandular  epithelium  by  infiltrating  lymphoma  cells  are  characteristic  of  MALT  lymphomas,  especially  those  affecting  the  stomach.The  WHO  also  recognize  three  provisional  entities:—  Extranodal  marginal  zone  lymphoma  (EMZL)  of  the  MALT  type.—  Splenic  marginal  zone  lymphoma  (SMZL).—  Nodal  marginal  zone  lymphoma  (NMZL).