RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189335812
T1 Myeloma
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189335812
RD 2024/04/25
AB Myeloma  is  a  malignancy  of  terminally  differentiated  B  cells  (plasma  cells)  that  produces  a  complete  monoclonal  immunoglobulin  (Ig)  protein  or  a  free  light  chain  (FLC).Clinical  and  laboratory  manifestations  are  heterogeneous  but  typically  include:—  A  monoclonal  Ig  in  plasma  and/or  monoclonal  light  chains  in  plasma  and  urine.  In  rare  cases,  the  cells  do  not  secrete  a  monoclonal  protein  in  the  plasma.—  Decreased  polyclonal  Ig  secretion  by  residual  normal  plasma  cells,  which  predisposes  to  infections.—  Hypercalcemia  as  a  result  of  osteolysis.—  Renal  dysfunction  as  a  result  of  light  chain  casts  or  hypercalcemia.—  Myeloma  cell  proliferation  in  marrow  leading  to  impaired  hematopoiesis.—  Osteolytic  bone  disease.