RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Linch, David C.
SR Print(0)
ID 1189336813
T1 Hereditary Thrombophilia
T2 Williams Manual of Hematology, 10e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269204
LK hemonc.mhmedical.com/content.aspx?aid=1189336813
RD 2024/04/23
AB Risk  factors  for  thromboembolism  may  be  genetic  or  acquired  (Table  89–1).Hereditary  thrombophilia  is  a  genetically  determined  increased  risk  of  thrombosis.  These  same  risk  factors  may  predispose  for  complications  of  pregnancy  (recurrent  miscarriage,  fetal  death,  etc.)Up  to  50%  of  patients  presenting  with  a  first  deep  venous  thrombosis  will  have  an  abnormal  laboratory  test  suggesting  a  thrombophilic  defect,  and  patients  with  recurrent  thromboses  or  with  a  strong  family  history  are  even  more  likely  to  have  laboratory  evidence  of  a  thrombophilic  state  (Table  89–1).Up  to  16%  of  patients  with  thrombophilia  have  inherited  more  than  one  abnormality.These  inherited  defects  also  interact  frequently  with  acquired  risk  factors,  such  as  inactivity,  trauma,  malignancy,  or  oral  contraceptive  use,  to  lead  to  clinical  thrombosis.There  are  several  reasons  tests  for  thrombophilia  can  be  false  positive,  as  listed  in  Table  89–2.The  relative  risks  for  venous  thromboembolism,  arterial  thrombotic  events,  and  pregnancy  complications  are  summarized  in  Table  89–3.