RT Book, Section A1 Buxton, Iain L. O. A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193226397 T1 Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK hemonc.mhmedical.com/content.aspx?aid=1193226397 RD 2024/03/29 AB The human body restricts access to foreign molecules; therefore, to reach its target within the body and have a therapeutic effect, a drug molecule must cross several restrictive barriers en route to its target site. Following administration, the drug must be absorbed and distributed, usually via vessels of the circulatory and lymphatic systems. In addition to crossing membrane barriers, the drug must survive metabolism (primarily hepatic) and elimination (by the kidney and liver and in the feces). ADME, the absorption, distribution, metabolism, and elimination of drugs, are the processes of pharmacokinetics (Figure 2–1). Understanding these processes and their interplay and employing pharmacokinetic principles increase the probability of therapeutic success and reduce the occurrence of adverse drug events and drug-drug interactions.