RT Book, Section A1 Hill, Matthew N. A1 Mackie, Ken A2 Brunton, Laurence L. A2 Knollmann, Björn C. SR Print(0) ID 1193231463 T1 Cannabinoids T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition YR 2023 FD 2023 PB McGraw-Hill Education PP New York, NY SN 9781264258079 LK hemonc.mhmedical.com/content.aspx?aid=1193231463 RD 2024/10/03 AB The psychoactive and medicinal properties of Cannabis species have been appreciated for millennia. However, only recently have we developed an understanding of the compounds present in cannabis that produce these effects. The primary psychoactive compounds in cannabis are the phytocannabinoids, which are meroterpenoids typically synthesized from olivetolic acid and geranyl pyrophosphate. Δ9-Tetrahydrocannabinol (THC) is the phytocannabinoid responsible for the characteristic psychoactivity of Cannabis. Another major phytocannabinoid, cannabidiol (CBD), may have distinct therapeutic benefits. The effects of other phytocannabinoids are less well understood. THC produces its effects by engaging the endocannabinoid system, an endogenous signaling system comprised of endogenous cannabinoids (endocannabinoids), endocannabinoid receptors, and the enzymes responsible for endocannabinoid synthesis and degradation. The endocannabinoid system is widespread throughout the body and is involved in regulation of stress, pain, reward, metabolism, and inflammation, among other physiological actions.