RT Book, Section
A1 Free, R. Benjamin
A1 Underhill, Suzanne M.
A1 Amara, Susan G.
A1 Sibley, David R.
A2 Brunton, Laurence L.
A2 Knollmann, Björn C.
SR Print(0)
ID 1193229145
T1 Neurotransmission in the Central Nervous System
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264258079
LK hemonc.mhmedical.com/content.aspx?aid=1193229145
RD 2024/04/25
AB The  brain  is  a  complex  assembly  of  interacting  cells  that  regulate  many  of  life’s  activities  in  a  dynamic  fashion,  generally  through  a  communication  process  termed  neurotransmission.  Because  the  CNS  drives  so  many  physiological  responses,  it  stands  to  reason  that  centrally  acting  drugs  are  invaluable  for  a  plethora  of  conditions.  CNS-acting  drugs  are  used  not  only  to  treat  anxiety,  depression,  mania,  and  schizophrenia,  but  also  to  target  diverse  pathophysiological  conditions  such  as  pain,  fever,  movement  disorders,  insomnia,  eating  disorders,  nausea,  vomiting,  and  migraine.  However,  as  the  CNS  dictates  such  diverse  physiology,  the  recreational  use  of  some  CNS-acting  drugs  can  and  does  lead  to  physical  dependence  (see  Chapter  28)  with  enormous  societal  impacts.  The  sheer  breadth  of  physiological  and  pathological  activities  mediated  by  drug  molecules  acting  in  the  CNS  makes  this  class  of  therapeutics  both  wide-ranging  and  important.