RT Book, Section A1 Downs, Levi S. A1 Carter, Jori S. A2 Karlan, Beth Y. A2 Bristow, Robert E. A2 Li, Andrew J. SR Print(0) ID 1106569934 T1 Preinvasive Disease of the Lower Genital Tract T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071749268 LK hemonc.mhmedical.com/content.aspx?aid=1106569934 RD 2024/10/14 AB Over the past 3 decades, the work of population scientists, laboratory-based researchers, and clinicians has together promoted the understanding of the pathogenesis of preinvasive disease of the lower genital tract and its associated cancers. Elucidating the progression from preinvasive disease to invasive cancer was the first step in implementing the Pap test as one of the most successful cancer screening program in developed nations and has dramatically lessened the impact of cervical cancer in the United States and other developed countries. Furthermore, with the identification of the human papillomavirus (HPV) as the principal and necessary cause of cervical cancer, the development and application of HPV vaccines will potentially further reduce the burden of cervical cancer and other HPV-induced malignancies.