RT Book, Section A1 Singh, Diljeet K. A2 Karlan, Beth Y. A2 Bristow, Robert E. A2 Li, Andrew J. SR Print(0) ID 1106570459 T1 Gestational Trophoblastic Disease T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071749268 LK hemonc.mhmedical.com/content.aspx?aid=1106570459 RD 2024/03/28 AB Gestational trophoblastic disease (GTD) represents a spectrum of cellular proliferations arising from the villous trophoblast of the placenta and encompasses 4 clinicopathologic entities: hydatidiform mole (complete and partial), invasive mole, choriocarcinoma (CCA), and placental site trophoblastic tumor (PSTT). The last 3 conditions are associated with more significant clinical sequelae and together comprise the general term gestational trophoblastic neoplasia (GTN). In the absence of GTD, a normal pregnancy involves functioning trophoblast that invades the endometrium and recruits a robust vasculature to develop the placenta, which supports intrauterine fetal development. In healthy trophoblastic tissue, these "cancer simulating" behaviors are highly regulated; however, in GTD, normal control mechanisms fail, leading to invasive, vascular tumors with a tendency to metastasize.1