RT Book, Section
A1 Freud, Aharon G.
A1 Caligiuri, Michael A.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121088799
T1 The Organization and Structure of Lymphoid Tissues
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121088799
RD 2024/04/24
AB SUMMARYThe  lymphoid  tissues  can  be  divided  into  primary  and  secondary  lymphoid  organs.*  Primary  lymphoid  tissues  are  sites  where  lymphocytes  develop  from  progenitor  cells  into  functional  and  mature  lymphocytes.  The  major  primary  lymphoid  tissue  is  the  marrow,  the  site  where  all  lymphocyte  progenitor  cells  reside  and  initially  differentiate.  This  organ  is  discussed  in  Chap.  5.  The  other  primary  lymphoid  tissue  is  the  thymus,  the  site  where  progenitor  cells  derived  from  the  marrow  differentiate  into  mature  thymus-derived  (T)  cells.  Secondary  lymphoid  tissues  are  sites  where  lymphocytes  undergo  additional  maturation  and  also  interact  with  each  other  and  with  nonlymphoid  cells  to  generate  immune  responses  to  antigens.  These  tissues  include  the  spleen,  lymph  nodes,  and  mucosa-associated  lymphoid  tissues  such  as  tonsils.  The  structure  of  these  tissues  provides  insight  into  how  the  immune  system  discriminates  between  self-antigens  and  foreign  antigens  and  develops  the  capacity  to  orchestrate  a  variety  of  specific  and  nonspecific  defenses  against  invading  pathogens.