RT Book, Section A1 Weinstein, Robert A2 Kaushansky, Kenneth A2 Lichtman, Marshall A. A2 Prchal, Josef T. A2 Levi, Marcel M. A2 Press, Oliver W. A2 Burns, Linda J. A2 Caligiuri, Michael SR Print(0) ID 1121091024 T1 Therapeutic Apheresis: Indications, Efficacy, and Complications T2 Williams Hematology, 9e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071833004 LK hemonc.mhmedical.com/content.aspx?aid=1121091024 RD 2024/10/07 AB SUMMARYTherapeutic apheresis refers to several blood processing methods that are used in the treatment of diverse clinical conditions. In most cases, the disorders so treated are characterized by a specific qualitative or quantitative abnormality of the blood. In hematologic practice, apheresis procedures are used to mitigate hyperviscosity in monoclonal protein disorders or remove pathologic autoantibodies and replete important plasma proteins. Red cell apheresis is used to improve the ratio of normal to abnormal red cells in hemoglobinopathies and protozoan disease, and to remove excess red cells, red cell-associated toxins, or excess iron from the body. Leukocyte apheresis is used to reduce the circulating blast count in acute leukemias with hyperleukocytosis and platelet apheresis is used to lower a very elevated platelet count in patients with myeloproliferative neoplasms. Photopheresis is used in the treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. Adverse effects of apheresis with current technologies are typically mild and, usually, do not prevent completion of therapy.