RT Book, Section
A1 Tolar, Jakub
A1 Osborn, Mark J
A1 Daughters, Randy
A1 Banga, Anannya
A1 Wagner, John
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121091169
T1 Regenerative Medicine: Multipotential Cell Therapy for Tissue Repair
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121091169
RD 2024/04/19
AB SUMMARYRegenerative  medicine  is  a  complex  and  rapidly  advancing  field  that  holds  tremendous  promise  in  treating,  and  even  curing,  many  diseases.  The  understanding  and  control  of  tissue  repair  is  one  of  the  most  urgent  challenges  in  medicine  today.  Regenerative  medicine  seeks  to  either  recruit  the  patient’s  reparative  cells  or  to  replace  the  malfunctioning  tissue  altogether  to  restore  the  deficient  organ  to  adequate  function.  The  common  link  among  all  types  of  regenerative  therapies  is  the  stem  cell,  which  gives  all  tissues  the  capacity  to  regenerate.  The  mechanisms  underlying  the  ability  of  a  progenitor  cell  to  differentiate  have  been  challenging  to  elucidate,  with  recent  experimentation  focused  on  editing  the  genome  itself.  It  has  been  even  more  difficult  to  determine  how  a  differentiated  cell  can  be  instructed  to  revert  to  an  immature  state  and  undergo  a  re-specification  to  another  differentiated  cellular  phenotype  or  an  asymmetrical  division  to  generate  more  immature  cells.  Our  ability  to  modify  genomes,  harness  stem  cells,  and  transplant  autologous  or  allogeneic  tissues  has  transformed  biomedical  inquiry  and  offers  hope  to  patients  with  diseases  spanning  all  organ  systems,  including  cardiac,  lung,  central  nervous  system,  and  liver  and  pancreatic  diseases.